Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC6731232 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Lu Yanyan Y Meng Ran R Wang Xiangyu X Xu Yajing Y Tang Yiting Y Wu Jianfeng J Xue Qianqian Q Yu Songlin S Duan Mingwu M Shan Dongyong D Wang Qingde Q Wang Haichao H Billiar Timothy R TR Xiao Xianzhong X Chen Fangping F Lu Ben B
Nature communications 20190906 1
Acute graft-versus-host disease (GVHD) remains a major obstacle for the wider usage of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is an effective therapy for hematopoietic malignancy. Here we show that caspase-11, the cytosolic receptor for bacterial endotoxin (lipopolysaccharide: LPS), enhances GVHD severity. Allo-HSCT markedly increases the LPS-caspase-11 interaction, leading to the cleavage of gasdermin D (GSDMD). Caspase-11 and GSDMD mediate the release of interleu ...[more]