Ontology highlight
ABSTRACT:
SUBMITTER: Hao Y
PROVIDER: S-EPMC6731260 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Hao Yi Y Fan Xinqi X Shi Yujie Y Zhang Che C Sun De-En DE Qin Ke K Qin Wei W Zhou Wen W Chen Xing X
Nature communications 20190906 1
Unnatural monosaccharides such as azidosugars that can be metabolically incorporated into cellular glycans are currently used as a major tool for glycan imaging and glycoproteomic profiling. As a common practice to enhance membrane permeability and cellular uptake, the unnatural sugars are per-O-acetylated, which, however, can induce a long-overlooked side reaction, non-enzymatic S-glycosylation. Herein, we develop 1,3-di-esterified N-azidoacetylgalactosamine (GalNAz) as next-generation chemical ...[more]