Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Q
PROVIDER: S-EPMC7148567 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Zhu Qiang Q Cheng Xuejun X Cheng Yaxian Y Chen Junchen J Xu Huan H Gao Yuntao Y Duan Xiaotao X Ji Junfeng J Li Xuekun X Yi Wen W
Proceedings of the National Academy of Sciences of the United States of America 20200319 14
Methionine metabolism is critical for the maintenance of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) pluripotency. However, little is known about the regulation of the methionine cycle to sustain ESC pluripotency. Here, we show that adenosylhomocysteinase (AHCY), an important enzyme in the methionine cycle, is critical for the maintenance and differentiation of mouse embryonic stem cells (mESCs). We show that mESCs exhibit high levels of methionine metabolism, whereas ...[more]