Ontology highlight
ABSTRACT:
SUBMITTER: Lakkadwala S
PROVIDER: S-EPMC6732022 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Lakkadwala Sushant S Dos Santos Rodrigues Bruna B Sun Chengwen C Singh Jagdish J
Journal of controlled release : official journal of the Controlled Release Society 20190626
Glioblastoma is a hostile brain tumor associated with high infiltration leading to poor prognosis. Anti-cancer chemotherapeutic agents have limited access into the brain due to the presence of the blood brain barrier (BBB). In this study, we designed a dual functionalized liposomal delivery system, surface modified with transferrin (Tf) for receptor mediated transcytosis and a cell penetrating peptide-penetratin (Pen) for enhanced cell penetration. We loaded doxorubicin and erlotinib into liposo ...[more]