Examining sex differences in pleiotropic effects for depression and smoking using polygenic and gene-region aggregation techniques.
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ABSTRACT:
SUBMITTER: Schmitz LL
PROVIDER: S-EPMC6732217 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Examining sex differences in pleiotropic effects for depression and smoking using polygenic and gene-region aggregation techniques.
Schmitz Lauren L LL Gard Arianna M AM Ware Erin B EB
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20190620 6
Sex differences in rates of depression are thought to contribute to sex differences in smoking initiation (SI) and number of cigarettes smoked per day (CPD). One hypothesis is that women smoke as a strategy to cope with anxiety and depression, and have difficulty quitting because of concomitant changes in hypothalamic-pituitary-adrenocortical (HPA) axis function during nicotine withdrawal states. Despite evidence of biological ties, research has not examined whether genetic factors that contribu ...[more]
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