Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity.

ABSTRACT:

Objective

Cold exposure increases energy expenditure (EE) and could have a role in combating obesity. To understand this potential, we determined the capacity for cold-induced thermogenesis (CIT), the EE increase above the basal metabolic rate at the individualized coldest tolerable temperature before overt shivering.

Design

During a 13-day inpatient protocol, we quantitated the EE of 12 lean men and 9 men with obesity at various randomly ordered ambient temperatures in a room calorimeter. Subjects underwent brown fat imaging after exposure to their coldest tolerable temperature.

Results

CIT capacity was 300 ± 218 kcal/d (mean ± SD) or 17 ± 11% in lean men and 125 ± 146 kcal/d or 6 ± 7% in men with obesity (P = 0.01). The temperature below which EE increased, lower cr

SUBMITTER: Brychta RJ 

PROVIDER: S-EPMC6733495 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature