Ontology highlight
ABSTRACT:
SUBMITTER: Eriksson SE
PROVIDER: S-EPMC6734141 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Eriksson Sofi E SE Ceder Sophia S Bykov Vladimir J N VJN Wiman Klas G KG
Journal of molecular cell biology 20190401 4
The TP53 tumor suppressor gene encodes a DNA-binding transcription factor that regulates multiple cellular processes including cell growth and cell death. The ability of p53 to bind to DNA and activate transcription is tightly regulated by post-translational modifications and is dependent on a reducing cellular environment. Some p53 transcriptional target genes are involved in regulation of the cellular redox homeostasis, e.g. TIGAR and GLS2. A large fraction of human tumors carry TP53 mutations ...[more]