Ontology highlight
ABSTRACT:
SUBMITTER: Suryadevara V
PROVIDER: S-EPMC6734379 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Suryadevara Vidyani V Huang Longshuang L Kim Seok-Jo SJ Cheresh Paul P Shaaya Mark M Bandela Mounica M Fu Panfeng P Feghali-Bostwick Carol C Di Paolo Gilbert G Kamp David W DW Natarajan Viswanathan V
American journal of physiology. Lung cellular and molecular physiology 20190515 2
Idiopathic pulmonary fibrosis (IPF) is a pernicious lung disease characterized by alveolar epithelial apoptosis, dysregulated repair of epithelial injury, scar formation, and respiratory failure. In this study, we identified phospholipase D (PLD)-generated phosphatidic acid (PA) signaling in the development of pulmonary fibrosis (PF). Of the PLD isoenzymes, the protein expression of PLD2, but not PLD1, was upregulated in lung tissues from IPF patients and bleomycin challenged mice. Both PLD1 (<i ...[more]