Ontology highlight
ABSTRACT:
SUBMITTER: Zhao C
PROVIDER: S-EPMC6735223 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Zhao Chunle C He Ruizhi R Shen Ming M Zhu Feng F Wang Min M Liu Yuhui Y Chen Hua H Li Xu X Qin Renyi R
Frontiers in pharmacology 20190903
Pancreatic cancer (PC) is one of the most lethal diseases, and effective treatment of PC patients remains an enormous challenge. Rocaglamide A (Roc-A), a bioactive molecule extracted from the plant <i>Aglaia elliptifolia</i>, has aroused considerable attention as a therapeutic choice for numerous cancer treatments. Nevertheless, the effects and underlying mechanism of Roc-A in PC are still poorly understood. Here, we found that Roc-A inhibited growth and stimulated apoptosis by induction of mito ...[more]