Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Pastor L
PROVIDER: S-EPMC6735912 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
García-Pastor Lucía L Sánchez-Romero María A MA Jakomin Marcello M Puerta-Fernández Elena E Casadesús Josep J
Nucleic acids research 20190901 15
Bistable expression of the Salmonella enterica std operon is controlled by an AND logic gate involving three transcriptional activators: the LysR-type factor HdfR and the StdE and StdF regulators encoded by the std operon itself. StdE activates transcription of the hdfR gene, and StdF activates std transcription together with HdfR. Binding of HdfR upstream of the std promoter is hindered by methylation of GATC sites located within the upstream activating sequence (UAS). Epigenetic control by Dam ...[more]