Ontology highlight
ABSTRACT:
SUBMITTER: Rezazadeh S
PROVIDER: S-EPMC6736037 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nucleic acids research 20190901 15
SIRT6 is critical for activating transcription of Nuclear factor (erythroid-derived 2)-like 2 (NRF2) responsive genes during oxidative stress. However, while the mechanism of SIRT6-mediated silencing is well understood, the mechanism of SIRT6-mediated transcriptional activation is unknown. Here, we employed SIRT6 separation of function mutants to reveal that SIRT6 mono-ADP-ribosylation activity is required for transcriptional activation. We demonstrate that SIRT6 mono-ADP-ribosylation of BAF170, ...[more]