Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients.
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ABSTRACT:
SUBMITTER: Pintarelli G
PROVIDER: S-EPMC6736939 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients.
Pintarelli Giulia G Noci Sara S Maspero Davide D Pettinicchio Angela A Dugo Matteo M De Cecco Loris L Incarbone Matteo M Tosi Davide D Santambrogio Luigi L Dragani Tommaso A TA Colombo Francesca F
Scientific reports 20190910 1
Alterations in the gene expression of organs in contact with the environment may signal exposure to toxins. To identify genes in lung tissue whose expression levels are altered by cigarette smoking, we compared the transcriptomes of lung tissue between 118 ever smokers and 58 never smokers. In all cases, the tissue studied was non-involved lung tissue obtained at lobectomy from patients with lung adenocarcinoma. Of the 17,097 genes analyzed, 357 were differentially expressed between ever smokers ...[more]
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