Identification of a Kavain Analog with Efficient Anti-inflammatory Effects.
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ABSTRACT:
SUBMITTER: Huck O
PROVIDER: S-EPMC6737110 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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Identification of a Kavain Analog with Efficient Anti-inflammatory Effects.
Huck Olivier O Han Xiaxian X Mulhall Hannah H Gumenchuk Iryna I Cai Bin B Panek James J Iyer Radha R Amar Salomon S
Scientific reports 20190910 1
Kavain, a compound derived from Piper methysticum, has demonstrated anti-inflammatory properties. To optimize its drug properties, identification and development of new kavain-derived compounds was undertaken. A focused library of analogs was synthesized and their effects on Porphyromonas gingivalis (P. gingivalis) elicited inflammation were evaluated in vitro and in vivo. The library contained cyclohexenones (5,5-dimethyl substituted cyclohexenones) substituted with a benzoate derivative at the ...[more]
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