Ontology highlight
ABSTRACT:
SUBMITTER: Feng X
PROVIDER: S-EPMC6737937 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Feng Xiaodong X Arang Nadia N Rigiracciolo Damiano Cosimo DC Lee Joo Sang JS Yeerna Huwate H Wang Zhiyong Z Lubrano Simone S Kishore Ayush A Pachter Jonathan A JA König Gabriele M GM Maggiolini Marcello M Kostenis Evi E Schlaepfer David D DD Tamayo Pablo P Chen Qianming Q Ruppin Eytan E Gutkind J Silvio JS
Cancer cell 20190214 3
Activating mutations in GNAQ/GNA11, encoding Gαq G proteins, are initiating oncogenic events in uveal melanoma (UM). However, there are no effective therapies for UM. Using an integrated bioinformatics pipeline, we found that PTK2, encoding focal adhesion kinase (FAK), represents a candidate synthetic lethal gene with GNAQ activation. We show that Gαq activates FAK through TRIO-RhoA non-canonical Gαq-signaling, and genetic ablation or pharmacological inhibition of FAK inhibits UM growth. Analysi ...[more]