Ontology highlight
ABSTRACT:
SUBMITTER: Tang P
PROVIDER: S-EPMC6737984 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Biology open 20190823 8
Stem/progenitor cells are maintained by a chromatin environment, mediated in part by Polycomb group (PcG) proteins, which depress differentiation. The trophoblast-specific PcG protein SFMBT2 is known to be required for maintenance of trophoblast progenitors. Rather than binding to trophoblast-specific genes repressed in TSC, SFMBT2 is concentrated at chromocentres and regions rich in repetitive elements, specifically LINE sequences and major satellites, suggesting that it is involved in higher-o ...[more]