Transcriptomics

Dataset Information

0

Unique Trophoblast Chromatin Environment Mediated by the PcG Protein SFMBT2 [RNA-seq]


ABSTRACT: Sfmbt2 is a paternally imprinted gene critical for the establishment and maintenance of trophoblast stem cells in mice (Miri K et al., 2013). Inheritance of a paternal Sfmbt2 gene trap null allele (Sfmbt2gt/gt) results in embryonic lethality by e12.5 due to reduced numbers in all trophoblast cell types. Of note, SFMBT2 is characterized as a Polycomb group (PcG) protein and is assumed to act as a master transcriptional repressor. Through RNA-seq analysis of extraembryonic tissues acquired from both wild-type and Sfmbt2gt/gt embryos, we aim to elucidate differentially expressed genes critical for the dramatic phenotype observed in mutant embryos.

ORGANISM(S): Mus musculus

PROVIDER: GSE117879 | GEO | 2019/08/18

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2019-08-18 | GSE115087 | GEO
| PRJNA483475 | ENA
| PRJNA473701 | ENA
| PRJNA483478 | ENA
2020-02-29 | GSE129939 | GEO
2020-02-29 | GSE129541 | GEO
| S-EPMC2220043 | biostudies-literature
| S-EPMC6737984 | biostudies-literature
2017-02-01 | GSE82054 | GEO
2017-02-01 | GSE82053 | GEO