Ontology highlight
ABSTRACT:
SUBMITTER: Spielmann K
PROVIDER: S-EPMC6739137 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20190829 36
The first catalytic enantioselective carbonyl (α-amino)allylations are described. Phthalimido-allene <b>1</b> and primary alcohols <b>2a</b>-<b>2z</b>, <b>2a'</b>-<b>2c'</b> engage in hydrogen auto-transfer-mediated carbonyl reductive coupling by way of (α-amino)allyliridium-aldehyde pairs to form vicinal amino alcohols <b>3a</b>-<b>3z</b>, <b>3a'</b>-<b>3c'</b> with high levels of regio-, <i>anti</i>-diastereo-, and enantioselectivity. Reaction progress kinetic analysis and isotopic labeling st ...[more]