Ontology highlight
ABSTRACT:
SUBMITTER: Huang ZL
PROVIDER: S-EPMC6740344 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
Huang Zhi-Li ZL Sato Yo Y Mochizuki Takatoshi T Okada Tetsuya T Qu Wei-Min WM Yamatodani Atsushi A Urade Yoshihiro Y Hayaishi Osamu O
The Journal of neuroscience : the official journal of the Society for Neuroscience 20030701 14
Prostaglandin (PG)E2 promotes the wakeful state when administered into the posterior hypothalamus, in which the histaminergic tuberomammillary nucleus (TMN) is located. To explore the neurotransmitter mechanisms responsible for PGE2-induced wakefulness in rats, we examined the effect of PGE2 on the activity of the histaminergic system and the involvement of PGE2 receptor subtypes in the response. PGE2 perfusion in the TMN at doses of 100, 200, and 400 pmol/min for 2 hr significantly increased hi ...[more]