Ontology highlight
ABSTRACT:
SUBMITTER: Gall D
PROVIDER: S-EPMC6740583 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
Gall David D Roussel Céline C Susa Isabella I D'Angelo Egidio E Rossi Paola P Bearzatto Bertrand B Galas Marie Christine MC Blum David D Schurmans Stéphane S Schiffmann Serge N SN
The Journal of neuroscience : the official journal of the Society for Neuroscience 20031001 28
Calcium-binding proteins such as calretinin are abundantly expressed in distinctive patterns in the CNS, but their physiological function remains poorly understood. Calretinin is expressed in cerebellar granule cells, which provide the major excitatory input to Purkinje cells through parallel fibers. Calretinin-deficient mice exhibit dramatic alterations in motor coordination and Purkinje cell firing recorded in vivo through unknown mechanisms. In the present study, we used patch-clamp recording ...[more]