Ontology highlight
ABSTRACT:
SUBMITTER: Seja P
PROVIDER: S-EPMC3297995 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Seja Patricia P Schonewille Martijn M Spitzmaul Guillermo G Badura Aleksandra A Klein Ilse I Rudhard York Y Wisden William W Hübner Christian A CA De Zeeuw Chris I CI Jentsch Thomas J TJ
The EMBO journal 20120117 5
Cerebellar cortical throughput involved in motor control comprises granule cells (GCs) and Purkinje cells (PCs), both of which receive inhibitory GABAergic input from interneurons. The GABAergic input to PCs is essential for learning and consolidation of the vestibulo-ocular reflex, but the role of GC excitability remains unclear. We now disrupted the Kcc2 K-Cl cotransporter specifically in either cell type to manipulate their excitability and inhibition by GABA(A)-receptor Cl(-) channels. Altho ...[more]