Ontology highlight
ABSTRACT:
SUBMITTER: Atwal JK
PROVIDER: S-EPMC6740747 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Atwal Jasvinder K JK Singh Karun K KK Tessier-Lavigne Marc M Miller Freda D FD Kaplan David R DR
The Journal of neuroscience : the official journal of the Society for Neuroscience 20030801 20
Peripheral nerve growth is regulated by the coordinated action of numerous external stimuli, including positively acting neurotrophin-derived growth cues and restrictive semaphorin cues. Here, we show that Semaphorin 3F (Sema 3F) can antagonize nerve growth factor (NGF)-stimulated TrkA (tyrosine receptor kinase A) signaling in sympathetic neurons, thereby apparently contributing to growth cone collapse. Sema 3F suppressed NGF-induced activation of the phosphatidylinositol 3 (PI3)-kinase-Akt and ...[more]