Ontology highlight
ABSTRACT:
SUBMITTER: Kesavapany S
PROVIDER: S-EPMC6741199 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
Kesavapany Sashi S Lau Kwok-Fai KF Ackerley Steven S Banner Steven J SJ Shemilt Stephen J A SJ Cooper Jonathan D JD Leigh P Nigel PN Shaw Christopher E CE McLoughlin Declan M DM Miller Christopher C J CC
The Journal of neuroscience : the official journal of the Society for Neuroscience 20030601 12
Here we characterize a novel neuronal kinase, cyclin-dependent kinase 5 (cdk5)/p35-regulated kinase (cprk). Cprk is a member of a previously undescribed family of kinases that are predicted to contain two N-terminal membrane-spanning domains and a long C terminus, which harbors a dual-specificity serine/threonine/tyrosine kinase domain. Cprk was isolated in a yeast two-hybrid screen using the neuronal cdk5 activator p35 as "bait." Cprk interacts with p35 in the yeast-two hybrid system, binds to ...[more]