Ontology highlight
ABSTRACT:
SUBMITTER: Saito T
PROVIDER: S-EPMC6742280 | biostudies-literature | 2003 Feb
REPOSITORIES: biostudies-literature
Saito Taro T Onuki Reiko R Fujita Yuichi Y Kusakawa Gen-ichi G Ishiguro Koichi K Bibb James A JA Kishimoto Takeo T Hisanaga Shin-ichi S
The Journal of neuroscience : the official journal of the Society for Neuroscience 20030201 4
Cyclin-dependent kinase 5 (Cdk5), a cdc2-related kinase expressed in postmitotic neurons, is activated by association with a brain-specific activator, p35. It has been suggested that the conversion of p35 to p25 by the protease calpain is involved in neuronal cell death. However, p35 protein is turned over rapidly via proteasomal degradation in living neurons. In this study we show that the phosphorylation of p35 by Cdk5 suppresses the cleavage to p25 by calpain, whereas phosphorylation facilita ...[more]