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(E)-Di-iodination of Alkynes Using Dried Dowex H⁺/NaI Approach.

ABSTRACT: We investigated the usefulness of the dried Dowex H⁺/NaI approach for the selective di-iodination of alkynes. The Dowex H⁺/NaI approach selectively produces only (E)-di-iodinated products; it is very straightforward and nontoxic. The utilization of 2-propanol as a solvent in the reactions can be considered as a "green" approach and the method maybe extended to radio-iodination. The method allows access to highly important building blocks. An initial example of the di-iodination and esterification in the same one-pot reaction is also presented.

SUBMITTER: Timonen JM

PROVIDER: S-EPMC6741282 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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(E)-Di-iodination of Alkynes Using Dried Dowex H+/NaI Approach.

Timonen Juri M JM Turhanen Petri A PA

ACS omega 20190827 11

We investigated the usefulness of the dried Dowex H+/NaI approach for the selective di-iodination of alkynes. The Dowex H+/NaI approach selectively produces only (E)-di-iodinated products; it is very straightforward and nontoxic. The utilization of 2-propanol as a solvent in the reactions can be considered as a "green" approach and the method maybe extended to radio-iodination. The method allows access to highly important building blocks. An initial example of the di ...[more]

PMID: 31528823

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