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Ligand-Enabled Pd(II)-Catalyzed Bromination and Iodination of C(sp3)-H Bonds.

ABSTRACT: We herein report the palladium(II)-catalyzed bromination and iodination of a variety of ?-hydrogen-containing carboxylic acid and amino acid-derived amides. These reactions are exclusively enabled by quinoline-type ligands. The halogenated products obtained in this reaction are highly versatile and rapidly undergo further diversification. Further, we report the first example of a free carboxylic acid-directed Pd(II)-catalyzed C(sp3)-H bromination, enabled by quinoline ligands.

SUBMITTER: Zhu RY 

PROVIDER: S-EPMC5535776 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Ligand-Enabled Pd(II)-Catalyzed Bromination and Iodination of C(sp<sup>3</sup>)-H Bonds.

Zhu Ru-Yi RY   Saint-Denis Tyler G TG   Shao Ying Y   He Jian J   Sieber Joshua D JD   Senanayake Chris H CH   Yu Jin-Quan JQ  

Journal of the American Chemical Society 20170413 16

We herein report the palladium(II)-catalyzed bromination and iodination of a variety of α-hydrogen-containing carboxylic acid and amino acid-derived amides. These reactions are exclusively enabled by quinoline-type ligands. The halogenated products obtained in this reaction are highly versatile and rapidly undergo further diversification. Further, we report the first example of a free carboxylic acid-directed Pd(II)-catalyzed C(sp<sup>3</sup>)-H bromination, enabled by quinoline ligands. ...[more]

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