Interferon-? in the context of viral infections: production, response and therapeutic implications.

ABSTRACT: Interferon (IFN)-? forms the type III IFN family. Although they signal through distinct receptors, type I (IFN-?/?) and type III IFNs elicit remarkably similar responses in cells. However, in vivo, type III and type I IFN responses are not fully redundant as their respective contribution to the antiviral defense highly depends on virus species. IFN-? is much more potent than IFN-?/? at controlling rotavirus infection. In contrast, clearance of several other viruses, such as influenza virus, mostly depends on IFN-?/?. The IFN-? receptor was reported to be preferentially expressed on epithelial cells. Cells responsible for IFN-? production are still poorly characterized but seem to overlap only partly IFN-?/?-producing cells. Accumulating data suggest that epithelial cells are also important IFN-? producers. Thus, IFN-? may primarily act as a protection of mucosal entities, such as the lung, skin or digestive tract. Type I and type III IFN signal transduction pathways largely overlap, and cross talk between these IFN systems occurs. Finally, this review addresses the potential benefit of IFN-? use for therapeutic purposes and summarizes recent results of genome-wide association studies that identified polymorphisms in the region of the IFN-?3 gene impacting on the outcome of treatments against hepatitis C virus infection.

SUBMITTER: Hermant P 

PROVIDER: S-EPMC6741612 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature