Ontology highlight
ABSTRACT:
SUBMITTER: Lozhkov AA
PROVIDER: S-EPMC7760417 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Lozhkov Alexey A AA Klotchenko Sergey A SA Ramsay Edward S ES Moshkoff Herman D HD Moshkoff Dmitry A DA Vasin Andrey V AV Salvato Maria S MS
Pathogens (Basel, Switzerland) 20201126 12
Interferons (IFN) are crucial for the innate immune response. Slightly more than two decades ago, a new type of IFN was discovered: the lambda IFN (type III IFN). Like other IFN, the type III IFN display antiviral activity against a wide variety of infections, they induce expression of antiviral, interferon-stimulated genes (<i>MX1</i>, <i>OAS</i>, <i>IFITM1</i>), and they have immuno-modulatory activities that shape adaptive immune responses. Unlike other IFN, the type III IFN signal through di ...[more]