Ontology highlight
ABSTRACT:
SUBMITTER: Ackley BD
PROVIDER: S-EPMC6742194 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
Ackley Brian D BD Kang Seong Hoon SH Crew Jennifer R JR Suh Chris C Jin Yishi Y Kramer James M JM
The Journal of neuroscience : the official journal of the Society for Neuroscience 20030501 9
Vertebrate neuromuscular junctions (NMJs) contain specialized basal laminas enriched for proteins not found at high concentrations extrasynaptically. Alterations in NMJ basement membrane components can result in loss of NMJ structural integrity and lead to muscular dystrophies. We demonstrate here that the conserved Caenorhabditis elegans basement membrane-associated molecules nidogen/entactin (NID-1) and type XVIII collagen (CLE-1) are associated with axons and particularly enriched near synapt ...[more]