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The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century.

ABSTRACT: We describe the epidemiological characteristics, pattern of circulation, and geographical distribution of influenza B viruses and its lineages using data from the Global Influenza B Study. We included over 1.8 million influenza cases occurred in thirty-one countries during 2000-2018. We calculated the proportion of cases caused by influenza B and its lineages; determined the timing of influenza A and B epidemics; compared the age distribution of B/Victoria and B/Yamagata cases; and evaluated the frequency of lineage-level mismatch for the trivalent vaccine. The median proportion of influenza cases caused by influenza B virus was 23.4%, with a tendency (borderline statistical significance, p = 0.060) to be higher in tropical vs. temperate countries. Influenza B was the dominant virus type in about one every seven seasons. In temperate countries, influenza B epidemics occurred on average three weeks later than influenza A epidemics; no consistent pattern emerged in the tropics. The two B lineages caused a comparable proportion of influenza B cases globally, however the B/Yamagata was more frequent in temperate countries, and the B/Victoria in the tropics (p = 0.048). B/Yamagata patients were significantly older than B/Victoria patients in almost all countries. A lineage-level vaccine mismatch was observed in over 40% of seasons in temperate countries and in 30% of seasons in the tropics. The type B virus caused a substantial proportion of influenza infections globally in the 21st century, and its two virus lineages differed in terms of age and geographical distribution of patients. These findings will help inform health policy decisions aiming to reduce disease burden associated with seasonal influenza.

SUBMITTER: Caini S

PROVIDER: S-EPMC6742362 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century.

Caini Saverio S Kusznierz Gabriela G Garate Verònica Vera VV Wangchuk Sonam S Thapa Binay B de Paula Júnior Francisco José FJ Ferreira de Almeida Walquiria Aparecida WA Njouom Richard R Fasce Rodrigo A RA Bustos Patricia P Feng Luzhao L Peng Zhibin Z Araya Jenny Lara JL Bruno Alfredo A de Mora Doménica D Barahona de Gámez Mónica Jeannette MJ Pebody Richard R Zambon Maria M Higueros Rocio R Rivera Rudevelinda R Kosasih Herman H Castrucci Maria Rita MR Bella Antonino A Kadjo Hervé A HA Daouda Coulibaly C Makusheva Ainash A Bessonova Olga O Chaves Sandra S SS Emukule Gideon O GO Heraud Jean-Michel JM Razanajatovo Norosoa H NH Barakat Amal A El Falaki Fatima F Meijer Adam A Donker Gé A GA Huang Q Sue QS Wood Tim T Balmaseda Angel A Palekar Rakhee R Arévalo Brechla Moreno BM Rodrigues Ana Paula AP Guiomar Raquel R Lee Vernon Jian Ming VJM Ang Li Wei LW Cohen Cheryl C Treurnicht Florette F Mironenko Alla A Holubka Olha O Bresee Joseph J Brammer Lynnette L Le Mai T Q MTQ Hoang Phuong V M PVM El Guerche-Séblain Clotilde C Paget John J

PloS one 20190912 9

We describe the epidemiological characteristics, pattern of circulation, and geographical distribution of influenza B viruses and its lineages using data from the Global Influenza B Study. We included over 1.8 million influenza cases occurred in thirty-one countries during 2000-2018. We calculated the proportion of cases caused by influenza B and its lineages; determined the timing of influenza A and B epidemics; compared the age distribution of B/Victoria and B/Yamagata cases; and evaluated the ...[more]

PMID: 31513690

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Dataset Information

The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century.

Publications

The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century.

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