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The Epidemiology and Burden of Influenza B/Victoria and B/Yamagata Lineages in Kenya, 2012-2016.


ABSTRACT: Background:The impact of influenza B virus circulation in Sub-Saharan Africa is not well described. Methods:We analyzed data from acute respiratory illness (ARI) in Kenya. We assessed clinical features and age-specific hospitalization and outpatient visit rates by person-years for influenza B/Victoria and B/Yamagata and the extent to which circulating influenza B lineages in Kenya matched the vaccine strain component of the corresponding season (based on Northern Hemisphere [October-March] and Southern Hemisphere [April-September] vaccine availability). Results:From 2012 to 2016, influenza B represented 31% of all influenza-associated ARIs detected (annual range, 13-61%). Rates of influenza B hospitalization and outpatient visits were higher for <5 vs ?5 years. Among <5 years, B/Victoria was associated with pneumonia hospitalization (64% vs 44%; P = .010) and in-hospital mortality (6% vs 0%; P = .042) compared with B/Yamagata, although the mean annual hospitalization rate for B/Victoria was comparable to that estimated for B/Yamagata. The 2 lineages co-circulated, and there were mismatches with available trivalent influenza vaccines in 2/9 seasons assessed. Conclusions:Influenza B causes substantial burden in Kenya, particularly among children aged <5 years, in whom B/Victoria may be associated with increased severity. Our findings suggest a benefit from including both lineages when considering influenza vaccination in Kenya.

SUBMITTER: Emukule GO 

PROVIDER: S-EPMC6804754 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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The Epidemiology and Burden of Influenza B/Victoria and B/Yamagata Lineages in Kenya, 2012-2016.

Emukule Gideon O GO   Otiato Fredrick F   Nyawanda Bryan O BO   Otieno Nancy A NA   Ochieng Caroline A CA   Ndegwa Linus K LK   Muturi Peter P   Bigogo Godfrey G   Verani Jennifer R JR   Muthoka Philip M PM   Hunsperger Elizabeth E   Chaves Sandra S SS  

Open forum infectious diseases 20190930 10


<h4>Background</h4>The impact of influenza B virus circulation in Sub-Saharan Africa is not well described.<h4>Methods</h4>We analyzed data from acute respiratory illness (ARI) in Kenya. We assessed clinical features and age-specific hospitalization and outpatient visit rates by person-years for influenza B/Victoria and B/Yamagata and the extent to which circulating influenza B lineages in Kenya matched the vaccine strain component of the corresponding season (based on Northern Hemisphere [Octob  ...[more]

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