Ontology highlight
ABSTRACT:
SUBMITTER: Tang A
PROVIDER: S-EPMC6742648 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Tang Aimin A Chen Zhifeng Z Cox Kara S KS Su Hua-Poo HP Callahan Cheryl C Fridman Arthur A Zhang Lan L Patel Sangita B SB Cejas Pedro J PJ Swoyer Ryan R Touch Sinoeun S Citron Michael P MP Govindarajan Dhanasekaran D Luo Bin B Eddins Michael M Reid John C JC Soisson Stephen M SM Galli Jennifer J Wang Dai D Wen Zhiyun Z Heidecker Gwendolyn J GJ Casimiro Danilo R DR DiStefano Daniel J DJ Vora Kalpit A KA
Nature communications 20190912 1
Respiratory syncytial virus (RSV) infection is the leading cause of hospitalization and infant mortality under six months of age worldwide; therefore, the prevention of RSV infection in all infants represents a significant unmet medical need. Here we report the isolation of a potent and broadly neutralizing RSV monoclonal antibody derived from a human memory B-cell. This antibody, RB1, is equipotent on RSV A and B subtypes, potently neutralizes a diverse panel of clinical isolates in vitro and d ...[more]