Ontology highlight
ABSTRACT:
SUBMITTER: McLellan JS
PROVIDER: S-EPMC4459498 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20130425 6136
The prefusion state of respiratory syncytial virus (RSV) fusion (F) glycoprotein is the target of most RSV-neutralizing activity in human sera, but its metastability has hindered characterization. To overcome this obstacle, we identified prefusion-specific antibodies that were substantially more potent than the prophylactic antibody palivizumab. The cocrystal structure for one of these antibodies, D25, in complex with the F glycoprotein revealed D25 to lock F in its prefusion state by binding to ...[more]