SR-BI Interactome Analysis Reveals a Proviral Role for UGGT1 in Hepatitis C Virus Entry.
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ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC6743029 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
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SR-BI Interactome Analysis Reveals a Proviral Role for UGGT1 in Hepatitis C Virus Entry.
Huang Jiazhao J Yin Han H Yin Peiqi P Jian Xia X Song Siqi S Luan Junwen J Zhang Leiliang L
Frontiers in microbiology 20190906
Hepatitis C virus (HCV) entry is mediated by multiple co-receptors including scavenger receptor class B, type I (SR-BI). To elucidate the interactome of human SR-BI, we performed immunoprecipitation (IP) experiment coupled with mass spectrometry (MS) analysis. UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1), a key component of calnexin cycle involved in protein glycosylation, was identified as a SR-BI-interacting protein. Silencing UGGT1 or N-glycosylation inhibitor treatment reduced SR-B ...[more]
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