Ontology highlight
ABSTRACT:
SUBMITTER: Lin Z
PROVIDER: S-EPMC6744271 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Lin Zhijie Z Yang Zhou Z Xie Ruiling R Ji Zeyang Z Guan Kunliang K Zhang Mingjie M
eLife 20190905
WW domain tandem-containing proteins such as KIBRA, YAP, and MAGI play critical roles in cell growth and polarity via binding to and positioning target proteins in specific subcellular regions. An immense disparity exists between promiscuity of WW domain-mediated target bindings and specific roles of WW domain proteins in cell growth regulation. Here, we discovered that WW domain tandems of KIBRA and MAGI, but not YAP, bind to specific target proteins with extremely high affinity and exquisite s ...[more]