Ontology highlight
ABSTRACT:
SUBMITTER: Talebizadeh Z
PROVIDER: S-EPMC6744835 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Talebizadeh Z Z Bittel D C DC Veatch O J OJ Kibiryeva N N Butler M G MG
Journal of autism and developmental disorders 20051001 5
Autism is a heterogeneous neurodevelopmental disorder with a 3-4 times higher sex ratio in males than females. X chromosome genes may contribute to this higher sex ratio through unusual skewing of X chromosome inactivation. We studied X chromosome skewness in 30 females with classical autism and 35 similarly aged unaffected female siblings as controls using the polymorphic androgen receptor (AR) gene. Significantly, increased X chromosome skewness (e.g., >80:20%) was detected in our autism group ...[more]