Ontology highlight
ABSTRACT:
SUBMITTER: Kinjo K
PROVIDER: S-EPMC6979883 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Kinjo Kenichi K Yoshida Tomoko T Kobori Yoshitomo Y Okada Hiroshi H Suzuki Erina E Ogata Tsutomu T Miyado Mami M Fukami Maki M
Molecular and cellular pediatrics 20200124 1
<h4>Background</h4>X chromosome inactivation (XCI) is an indispensable process in the development of human female embryos. Reportedly, XCI occurs when a blastocyst contains 10-12 embryonic progenitor cells. To date, it remains unclear whether XCI ratios are normally preserved in Klinefelter syndrome (KS) patients with 47,XXY karyotype.<h4>Methods</h4>We examined XCI ratios in 18 KS patients through DNA methylation analysis for the polymorphic trinucleotide locus in the AR gene. The results of th ...[more]