Ontology highlight
ABSTRACT:
SUBMITTER: Ashouri JF
PROVIDER: S-EPMC6744919 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Ashouri Judith F JF Hsu Lih-Yun LY Yu Steven S Rychkov Dmitry D Chen Yiling Y Cheng Debra A DA Sirota Marina M Hansen Erik E Lattanza Lisa L Zikherman Julie J Weiss Arthur A
Proceedings of the National Academy of Sciences of the United States of America 20190827 37
How pathogenic cluster of differentiation 4 (CD4) T cells in rheumatoid arthritis (RA) develop remains poorly understood. We used Nur77-a marker of T cell antigen receptor (TCR) signaling-to identify antigen-activated CD4 T cells in the SKG mouse model of autoimmune arthritis and in patients with RA. Using a fluorescent reporter of Nur77 expression in SKG mice, we found that higher levels of Nur77-eGFP in SKG CD4 T cells marked their autoreactivity, arthritogenic potential, and ability to more r ...[more]