CSF evidence of pericyte damage in Alzheimer's disease is associated with markers of blood-brain barrier dysfunction and disease pathology.
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ABSTRACT:
SUBMITTER: Miners JS
PROVIDER: S-EPMC6745071 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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CSF evidence of pericyte damage in Alzheimer's disease is associated with markers of blood-brain barrier dysfunction and disease pathology.
Miners J S JS Kehoe P G PG Love S S Zetterberg H H Blennow K K
Alzheimer's research & therapy 20190914 1
<h4>Background</h4>We aimed to assess the relationship between levels of a cerebrospinal fluid (CSF) marker of pericyte damage, soluble platelet-derived growth factor receptor β (sPDGFRβ) and CSF markers of blood-brain barrier (BBB) integrity (CSF albumin and CSF/serum albumin ratio) and disease pathology (reduced CSF Aβ42 and elevated CSF total and phosphorylated tau) in Alzheimer's disease (AD).<h4>Methods</h4>sPDGFRβ and albumin were measured by sandwich ELISA in ante-mortem CSF from 39 AD an ...[more]
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