Ontology highlight
ABSTRACT:
SUBMITTER: Montagne A
PROVIDER: S-EPMC5679168 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Montagne Axel A Zhao Zhen Z Zlokovic Berislav V BV
The Journal of experimental medicine 20171023 11
The blood-brain barrier (BBB) keeps neurotoxic plasma-derived components, cells, and pathogens out of the brain. An early BBB breakdown and/or dysfunction have been shown in Alzheimer's disease (AD) before dementia, neurodegeneration and/or brain atrophy occur. However, the role of BBB breakdown in neurodegenerative disorders is still not fully understood. Here, we examine BBB breakdown in animal models frequently used to study the pathophysiology of AD, including transgenic mice expressing huma ...[more]