Ontology highlight
ABSTRACT:
SUBMITTER: Helleboid PY
PROVIDER: S-EPMC6745500 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Helleboid Pierre-Yves PY Heusel Moritz M Duc Julien J Piot Cécile C Thorball Christian W CW Coluccio Andrea A Pontis Julien J Imbeault Michaël M Turelli Priscilla P Aebersold Ruedi R Trono Didier D
The EMBO journal 20190812 18
Krüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) are encoded in the hundreds by the genomes of higher vertebrates, and many act with the heterochromatin-inducing KAP1 as repressors of transposable elements (TEs) during early embryogenesis. Yet, their widespread expression in adult tissues and enrichment at other genetic loci indicate additional roles. Here, we characterized the protein interactome of 101 of the ~350 human KZFPs. Consistent with their targeting of TEs, most K ...[more]