Ontology highlight
ABSTRACT:
SUBMITTER: Dagdeviren C
PROVIDER: S-EPMC6746310 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Dagdeviren Canan C Ramadi Khalil B KB Joe Pauline P Spencer Kevin K Schwerdt Helen N HN Shimazu Hideki H Delcasso Sebastien S Amemori Ken-Ichi KI Nunez-Lopez Carlos C Graybiel Ann M AM Cima Michael J MJ Langer Robert R
Science translational medicine 20180101 425
Recent advances in medications for neurodegenerative disorders are expanding opportunities for improving the debilitating symptoms suffered by patients. Existing pharmacologic treatments, however, often rely on systemic drug administration, which result in broad drug distribution and consequent increased risk for toxicity. Given that many key neural circuitries have sub-cubic millimeter volumes and cell-specific characteristics, small-volume drug administration into affected brain areas with min ...[more]