Ontology highlight
ABSTRACT:
SUBMITTER: Clayton GM
PROVIDER: S-EPMC6746357 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Clayton Gina M GM White Janice J Lee Schuyler S Kappler John W JW Chan Sanny K SK
PloS one 20190916 9
Lipocalins represent the most important protein family of the mammalian respiratory allergens. Four of the seven named dog allergens are lipocalins: Can f 1, Can f 2, Can f 4, and Can f 6. We present the structure of Can f 6 along with data on the biophysical and biological activity of this protein in comparison with other animal lipocalins. The Can f 6 structure displays the classic lipocalin calyx-shaped ligand binding cavity within a central β-barrel similar to other lipocalins. Despite low s ...[more]