Ontology highlight
ABSTRACT:
SUBMITTER: Nassa G
PROVIDER: S-EPMC6746822 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nassa Giovanni G Giurato Giorgio G Salvati Annamaria A Gigantino Valerio V Pecoraro Giovanni G Lamberti Jessica J Rizzo Francesca F Nyman Tuula A TA Tarallo Roberta R Weisz Alessandro A
Scientific data 20190916 1
Estrogen Receptor alpha (ERα) is a ligand-inducible transcription factor that mediates estrogen signaling in hormone-responsive cells, where it controls key cellular functions by assembling in gene-regulatory multiprotein complexes. For this reason, interaction proteomics has been shown to represent a useful tool to investigate the molecular mechanisms underlying ERα action in target cells. RNAs have emerged as bridging molecules, involved in both assembly and activity of transcription regulator ...[more]