Ontology highlight
ABSTRACT:
SUBMITTER: Chen K
PROVIDER: S-EPMC6749836 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Chen Kun K Luan Xiaoting X Liu Qisha Q Wang Jianwei J Chang Xinxia X Snijders Antoine M AM Mao Jian-Hua JH Secombe Julie J Dan Zhou Z Chen Jian-Huan JH Wang Zibin Z Dong Xiao X Qiu Chen C Chang Xiaoai X Zhang Dong D Celniker Susan E SE Liu Xingyin X
Cell host & microbe 20190319 4
Loss-of-function mutations in the histone demethylases KDM5A, KDM5B, or KDM5C are found in intellectual disability (ID) and autism spectrum disorders (ASD) patients. Here, we use the model organism Drosophila melanogaster to delineate how KDM5 contributes to ID and ASD. We show that reducing KDM5 causes intestinal barrier dysfunction and changes in social behavior that correlates with compositional changes in the gut microbiota. Therapeutic alteration of the dysbiotic microbiota through antibiot ...[more]