Ontology highlight
ABSTRACT:
SUBMITTER: Zhaunova L
PROVIDER: S-EPMC4975413 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Zhaunova Liudmila L Ohkura Hiroyuki H Breuer Manuel M
PLoS genetics 20160805 8
During prophase of the first meiotic division (prophase I), chromatin dynamically reorganises to recombine and prepare for chromosome segregation. Histone modifying enzymes are major regulators of chromatin structure, but our knowledge of their roles in prophase I is still limited. Here we report on crucial roles of Kdm5/Lid, one of two histone demethylases in Drosophila that remove one of the trimethyl groups at Lys4 of Histone 3 (H3K4me3). In the absence of Kdm5/Lid, the synaptonemal complex w ...[more]