Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC6750005 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Wu Xia X Siehnel Richard J RJ Garudathri Jayanthi J Staudinger Benjamin J BJ Hisert Katherine B KB Ozer Egon A EA Hauser Alan R AR Eng Jimmy K JK Manoil Colin C Singh Pradeep K PK Bruce James E JE
Journal of proteome research 20190522 6
Chronic airway infection with P. aeruginosa (PA) is a hallmark of cystic fibrosis (CF) disease. The mechanisms producing PA persistence in CF therapies remain poorly understood. To gain insight on PA physiology in patient airways and better understand how in vivo bacterial functioning differs from in vitro conditions, we investigated the in vivo proteomes of PA in 35 sputum samples from 11 CF patients. We developed a novel bacterial-enrichment method that relies on differential centrifugation an ...[more]