Dataset Information

Fast myocardial T₁ mapping using shortened inversion recovery based schemes.

ABSTRACT:

Background

Myocardial T₁ mapping shows promise for assessment of cardiomyopathies. Most myocardial T₁ mapping techniques, such as modified Look-Locker inversion recovery (MOLLI), generate one T₁ map per breath-held acquisition (9-17 heartbeats), which prolongs multislice protocols and may be unsuitable for patients with breath-holding difficulties.

Purpose

To develop and characterize novel shortened inversion recovery based T₁ mapping schemes of 2-5 heartbeats.

Study type

Prospective.

Population/phantom

Numerical simulations, agarose/NiCl₂ phantom, 16 healthy volunteers, and 24 patients.

Field strength/sequence

1.5T/MOLLI.

Assessment

All shortened T₁ mapping schemes were characterized and compared with a conventional MOLLI scheme (5-(3)-3) in terms of accuracy, precision, spatial variability, and repeatability.

Statistical tests

Kruskal-Wallis, Wilcoxon rank sum tests, analysis of variance, Student's t-tests, Bland-Altman analysis, and Pearson correlation analysis.

Results

All shortened schemes provided limited T₁ time variations (≤2% for T₁ times ≤1200 msec) and limited penalty of precision (by a factor of ~1.4-1.5) when compared with MOLLI in numerical simulations. In phantom, differences between all schemes in terms of accuracy, spatial variability, and repeatability did not reach statistical significance (P > 0.71). In healthy volunteers, there were no statistically significant differences between all schemes in terms of native T₁ times and repeatability for myocardium (P = 0.21 and P = 0.87, respectively) and blood (P = 0.79 and P = 0.41, respectively). All shortened schemes led to a limited increase of spatial variability for native myocardial T₁ mapping with respect to MOLLI (by a factor of 1.2) (P < 0.0001). In both healthy volunteers and patients, the two-heartbeat scheme and MOLLI led to highly linearly correlated T₁ times (correlation coefficients ≥0.83).

Data conclusion

The proposed two-heartbeat T₁ mapping scheme yields a 5-fold acceleration compared with MOLLI, with highly linearly correlated T₁ times, no significant difference of repeatability, and limited spatial variability penalty at 1.5T. This approach may enable myocardial T₁ mapping in patients with severe breath-holding difficulties and reduce the examination time of multislice protocols.

Level of evidence

1 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019;50:641-654.

SUBMITTER: Huang L

PROVIDER: S-EPMC6751084 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:BackgroundMyocardial T1-mapping recently emerged as a promising quantitative method for non-invasive tissue characterization in numerous cardiomyopathies. Commonly performed with an inversion-recovery (IR) magnetization preparation at 1.5T, the application at 3T has gained due to increased quantification precision. Alternatively, saturation-recovery (SR) T1-mapping has recently been introduced at 1.5T for improved accuracy. Thus, the purpose of this study is to investigate the robustness and precision of SR T1-mapping at 3T and to establish accurate reference values for native T1-times and extracellular volume fraction (ECV) of healthy myocardium.MethodsBalanced Steady-State Free-Precession (bSSFP) Saturation-Pulse Prepared Heart-rate independent Inversion-REcovery (SAPPHIRE) and Saturation-recovery Single-SHot Acquisition (SASHA) T1-mapping were compared with the Modified Look-Locker inversion recovery (MOLLI) sequence at 3T. Accuracy and precision were studied in phantom. Native and post-contrast T1-times and regional ECV were determined in 20 healthy subjects (10 men, 27 ± 5 years). Subjective image quality, susceptibility artifact rating, in-vivo precision and reproducibility were analyzed.ResultsSR T1-mapping showed <4 % deviation from the spin-echo reference in phantom in the range of T1 = 100-2300 ms. The average quality and artifact scores of the T1-mapping methods were: MOLLI:3.4/3.6, SAPPHIRE:3.1/3.4, SASHA:2.9/3.2; (1: poor - 4: excellent/1: strong - 4: none). SAPPHIRE and SASHA yielded significantly higher T1-times (SAPPHIRE: 1578 ± 42 ms, SASHA: 1523 ± 46 ms), in-vivo T1-time variation (SAPPHIRE: 60.1 ± 8.7 ms, SASHA: 70.0 ± 9.3 ms) and lower ECV-values (SAPPHIRE: 0.20 ± 0.02, SASHA: 0.21 ± 0.03) compared with MOLLI (T1: 1181 ± 47 ms, ECV: 0.26 ± 0.03, Precision: 53.7 ± 8.1 ms). No significant difference was found in the inter-subject variability of T1-times or ECV-values (T1: p = 0.90, ECV: p = 0.78), the observer agreement (inter: p > 0.19; intra: p > 0.09) or consistency (inter: p > 0.07; intra: p > 0.17) between the three methods.ConclusionsSaturation-recovery T1-mapping at 3T yields higher accuracy, comparable inter-subject, inter- and intra-observer variability and less than 30 % precision-loss compared to MOLLI.

Dataset Information

Fast myocardial T₁ mapping using shortened inversion recovery based schemes.

Background

Purpose

Study type

Population/phantom

Field strength/sequence

Assessment

Statistical tests

Results

Data conclusion

Level of evidence

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Fast myocardial T1 mapping using shortened inversion recovery based schemes.

Background

Purpose

Study type

Population/phantom

Field strength/sequence

Assessment

Statistical tests

Results

Data conclusion

Level of evidence

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Fast myocardial T₁ mapping using shortened inversion recovery based schemes.