Ontology highlight
ABSTRACT:
SUBMITTER: Altemus MA
PROVIDER: S-EPMC6752868 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Altemus Megan A MA Goo Laura E LE Little Andrew C AC Yates Joel A JA Cheriyan Hannah G HG Wu Zhi Fen ZF Merajver Sofia D SD
PloS one 20190919 9
In breast cancer, tumor hypoxia has been linked to poor prognosis and increased metastasis. Hypoxia activates transcriptional programs in cancer cells that lead to increased motility and invasion, as well as various metabolic changes. One of these metabolic changes, an increase in glycogen metabolism, has been further associated with protection from reactive oxygen species damage that may lead to premature senescence. Here we report that breast cancer cells significantly increase glycogen stores ...[more]