Ontology highlight
ABSTRACT:
SUBMITTER: Pero R
PROVIDER: S-EPMC6752957 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Pero Raffaela R Angrisano Tiziana T Brancaccio Mariarita M Falanga Annarita A Lombardi Lucia L Natale Francesco F Laneri Sonia S Lombardo Barbara B Galdiero Stefania S Scudiero Olga O
PloS one 20190919 9
Antimicrobial peptides can protect the gastric mucosa from bacteria, but Helicobacter pylori (H. pylori) can equally colonize the gastric apparatus. To understand beta-defensin function in H. pylori-associated chronic gastritis, we investigated susceptibility, human beta-defensin mRNA expression, and DNA methylation changes to promoters in the gastric mucosa with or without H. pylori infection. We studied the expression of HBD2 (gene name DEFB4A), HBD3 (DEFB103A), and HBD4 (DEFB104) using real-t ...[more]