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AKTivation mechanisms.

ABSTRACT: Akt1-3 (Akt) are a subset of the AGC protein Ser/Thr kinase family and play important roles in cell growth, metabolic regulation, cancer, and other diseases. We describe some of the roles of Akt in cell signaling and the biochemical and structural mechanisms of the regulation of Akt catalysis by the phospholipid PIP3 and by phosphorylation. Recent findings highlight a diverse set of strategies to control Akt catalytic activity to ensure its normal biological functions.

SUBMITTER: Cole PA

PROVIDER: S-EPMC6752985 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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AKTivation mechanisms.

Cole Philip A PA Chu Nam N Salguero Antonieta L AL Bae Hwan H

Current opinion in structural biology 20190320

Akt1-3 (Akt) are a subset of the AGC protein Ser/Thr kinase family and play important roles in cell growth, metabolic regulation, cancer, and other diseases. We describe some of the roles of Akt in cell signaling and the biochemical and structural mechanisms of the regulation of Akt catalysis by the phospholipid PIP3 and by phosphorylation. Recent findings highlight a diverse set of strategies to control Akt catalytic activity to ensure its normal biological functions. ...[more]

PMID: 30901610

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